Table of Contents:
RESEARCH PAPERS: TRAUMATIC BRAIN INJURY
- Executive summary: Secondary analyses of DoD-sponsored studies examining hyperbaric oxygen for persistent post-concussive symptoms after mild traumatic brain injury
OUTCOME ASSESSMENT TOOLS: NORMAL REFERENCE RANGES
- Reference ranges and stability of auditory and vestibular measures in a comprehensive assessment battery for traumatic brain injury
OUTCOME ASSESSMENT TOOLS: BASELINE ASSESSMENTS IN mTBI POPULATIONS
- Quantitative analysis tool for clinical functional MRI in mild traumatic brain injury
- Hidden hearing deficits in military service members with persistent post concussive symptoms
- Central auditory processing disorders after mild traumatic brain injury
- Prospective study of anxiety, post-traumatic stress and depression on postural control, gait, otolith and visuospatial function in military service members with persistent post-concussive symptoms
INTERVENTIONAL OUTCOMES IN HBO2 VERSUS SHAM AIR-EXPOSED mTBI POPULATIONS
- Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls
- Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms
- Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms
POOLED ANALYSES FROM mTBI STUDIES
- Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms
- A composite outcome for mild traumatic brain injury in trials of hyperbaric oxygen
- Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies
- To understand the purpose of the United States Department of Defense’s inquiry into hyperbaric oxygen for persistent problems after mild TBI.
- To gain a high-level overview of the findings from these studies.
- To understand the purpose of collecting normative data for clinical and research use.
- To describe the primary demographic factors that influence auditory and vestibular performance.
- To describe the general methods for interpreting clinical auditory functional MRI.
- To understand the barriers to implementation of auditory functional MRI in a research setting.
- To discuss possible explanations for auditory symptoms after mild traumatic brain injury that exceed damage detectable via pure tone audiometry.
- To understand the limitations of measurement technology in quantifying auditory dysfunction.
- To understand the effect of mild traumatic brain injury on central auditory processing, and the difference between those with and without clinical hearing loss.
- To determine the relationship, if any, between auditory pathway disruption and lateral auditory processing dysfunction.
- To understand the potential relationships between vestibular performance and symptoms of depression, anxiety, and post-traumatic stress in the military mild TBI population.
- To discuss recommendations for co-evaluation of vestibular function and affective symptoms in this population.
- To understand the role of MR spectroscopy in evaluation of mild traumatic brain injury.
- To describe limitations of the functional MRI technology for mild traumatic brain injury.
- To understand the relationship between eye movement behavior and mTBI.
- To identify specific tracking tasks and corresponding eye movement behaviors that are most sensitive to the effects of mTBI.
- To evaluate the sensitivity of eye tracking tasks as a measure of response for the treatment of mTBI.
- To discuss the long-term symptom course in study participants with mild traumatic brain injury.
- To describe effective strategies for retention of participants in longitudinal studies.
- To describe the safety of a course of 40 hyperbaric oxygen or sham chamber sessions in individuals with persistent post-concussive symptoms after mild traumatic brain injury.
- To describe effective methods for maintaining blinding in hyperbaric oxygen randomized trials.
- To understand the purpose of composite and global outcome measures in clinical trials.
- To describe the various methods of computing composite outcomes in the BIMA and HOPPS studies and to summarize those results.
- Understand the overall magnitude and direction of HBO2 eﬀects on PCS and PTSD symptoms, other self-report outcomes, and neuropsychological outcomes across all available studies.
- Identify whether treatment eﬀects observed in those with mTBI and oncomitant PTSD (mTBI + PTSD) diﬀer across outcomes from eﬀects observed in those with mTBI alone.
- Evaluate outcomes relative to increasing partial pressures of oxygen, to identify potential dose-response relationships and better understand the role of the sham control.
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|Name of Individual||Individuals Role in Activity||Name of Commercial Interest (If Applicable)||Nature of Relationship|
||Planner, Managing Editor
||Planner, CME Coordinator
|Enrico Camporesi, MD
|David Hostler, Phd
|Owen J. O’Neill, MD
|Tom Bozzuto, DO
|Michael Harl, MD
|Heather Murphy-Lavoie, MD
|N. Nicholas Vandemoer, MD
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